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Updated: Jun 16, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Molecular therapeutic approaches to melanoma
Zhenyu Ji1, Keith T Flaherty, Hensin Tsao
1Wellman Center for Photomedicine/Dept of Dermatology, 55 Fruit Street, Boston, MA 02114, USA.
Abstract:
Metastatic melanoma is a highly lethal cancer that has historically been refractory to all tested pharmacological agents. An understanding of the mechanisms responsible for its oncogenesis is critical for developing successful therapies. An enormous amount of data generated over the last few decades have revealed important biological insights into melanoma initiation, progression and maintenance, which bring new directions and approaches to treatment of this devastating skin cancer.
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