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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
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Updated: Jun 16, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Published on: June 3, 2020

Healthy brain aging: a road map.

Abhilash K Desai1, George T Grossberg, John T Chibnall

  • 1Department of Neurology and Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, 1438 South Grand Boulevard, St Louis, MO 63104, USA. adesai@slu.edu <adesai@slu.edu>

Clinics in Geriatric Medicine
|February 24, 2010
PubMed
Summary
This summary is machine-generated.

Preventing dementia involves managing vascular risk factors and adopting healthy lifestyle choices. Early intervention is crucial for preserving cognitive function and maintaining independence throughout aging.

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

  • Gerontology
  • Neurology
  • Public Health

Background:

  • Cognitive function is essential for quality of life, and dementia poses a significant threat to aging populations.
  • Dementias are among the most feared age-related conditions due to their debilitating effects.

Purpose of the Study:

  • To highlight the importance of dementia prevention strategies.
  • To integrate dementia prevention into existing public health initiatives for cardiovascular health.

Main Methods:

  • Reviewing evidence on vascular risk factors (obesity, hypertension, diabetes, smoking) and their role in dementia.
  • Examining the protective effects of psychosocial factors (education, exercise, diet, social engagement) on cognitive health.
  • Drawing parallels between stroke/myocardial infarction prevention and dementia prevention strategies.

Main Results:

  • Vascular factors significantly increase dementia risk, while positive lifestyle choices offer protection.
  • Interventions proven effective for cardiovascular disease prevention can be adapted for dementia prevention.
  • Early initiation of preventive measures is critical, considering age-related effects.

Conclusions:

  • Dementia prevention is a necessary addition to public health and aging-related disease prevention efforts.
  • Controlling vascular risk factors and promoting healthy lifestyles are key to preserving brain function.
  • Proactive, lifelong strategies are essential for combating dementia and maintaining cognitive vitality.