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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists
Rémy C Lemoine1, Ann C Petersen, Lina Setti
1Department of Medicinal Chemistry, Roche Palo Alto, Palo Alto, CA 94304, USA. remy.lemoine@roche.com
Abstract:
The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.
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