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Related Experiment Video

Updated: Jun 16, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Measurement precision in the optimization of cardiac resynchronization therapy.

Robert G Turcott1, Ronald M Witteles, Paul J Wang

  • 1Division of Cardiovascular Medicine and Center for Biomedical Informatics Research, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

Circulation. Heart Failure
|February 24, 2010
PubMed
Summary

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Optimizing atrioventricular (AV) and interventricular (VV) pacing intervals is crucial for cardiac resynchronization therapy. Impedance cardiography provides statistically significant data for AV/VV optimization, unlike echocardiography, ensuring improved cardiac function.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Clinical Electrophysiology

Background:

  • Cardiac resynchronization therapy (CRT) enhances outcomes in selected patients.
  • The impact of optimizing atrioventricular (AV) and interventricular (VV) pacing intervals on CRT efficacy is not fully understood.
  • Current methods for estimating optimal AV/VV intervals lack characterized precision and understanding of potential consequences.

Purpose of the Study:

  • To develop a method for quantifying the precision of estimated optimal AV/VV intervals.
  • To compare the effectiveness of different optimization techniques in individual patients.
  • To assess the clinical implications of imprecise AV/VV interval estimates.

Main Methods:

  • Developed an objective methodology to quantify the precision of estimated optimal AV/VV intervals.

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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

  • Conducted optimization in 20 patients using conventional techniques.
  • Measured stroke volume and dyssynchrony via impedance cardiography and echocardiography (aortic velocity-time integral, mitral velocity-time integral, A-wave truncation, septal-posterior wall motion delay).

    • Main Results:

    • Echocardiographic methods produced statistically insignificant data in 62%-82% of patients.
    • Impedance cardiography yielded statistically significant results for AV (84%) and VV (75%) interval optimization.
    • Imprecise AV/VV interval estimates can lead to diminished cardiac function compared to default settings.

    Conclusions:

    • Statistical significance is essential for validating individual patient optimization data and comparing techniques.
    • Accepting imprecise optimal intervals without assessing precision can worsen cardiac function and lead to misinterpretation.
    • Impedance cardiography proved superior, yielding statistically significant AV and VV optimization data in most patients.