Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes
09:41

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes

Published on: September 15, 2023

Female-specific flightless phenotype for mosquito control.

Guoliang Fu1, Rosemary S Lees, Derric Nimmo

  • 1Oxitec Limited, 71 Milton Park, Oxford OX14 4RX, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|February 24, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A major factor underlies biliverdin-mediated blue pigmentation in the Chinese oak silkworm Antheraea pernyi.

Insect biochemistry and molecular biology·2026
Same author

Correction: Comparative analysis of the Potter Tower and a new Track Sprayer for the application of residual sprays in the laboratory.

Parasites & vectors·2026
Same author

Compound effector genes suppress malaria parasite infections in gene-drive population modification strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii.

G3 (Bethesda, Md.)·2026
Same author

Advances in CRISPR gene drives for mosquito population control.

Current opinion in microbiology·2026
Same author

Susceptibility of <i>Anopheles stephensi</i> SDA500 strain to common insecticides and efficacy of glazed tile bioassay for resistance characterization.

Current research in parasitology & vector-borne diseases·2026
Same author

Conveyor belt speed detection via the synergistic fusion of optical flow and feature matching.

Scientific reports·2025
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

New transgenic Aedes aegypti mosquitoes offer a novel approach to dengue control. These genetically modified mosquitoes are engineered for male-only release, potentially reducing disease transmission and improving public health outcomes.

Area of Science:

  • Genetics
  • Entomology
  • Public Health

Background:

  • Dengue fever and dengue hemorrhagic fever pose significant global health challenges, with millions of new infections annually.
  • Aedes aegypti mosquitoes are the primary vectors for dengue viruses, making their control crucial for reducing human illness and death.
  • Current mosquito control methods are often insufficient, highlighting the urgent need for innovative strategies.

Purpose of the Study:

  • To develop a novel sterile-male-release strategy for controlling Aedes aegypti mosquito populations.
  • To engineer transgenic Aedes aegypti strains with a conditional, female-specific flightless phenotype for improved mosquito control.

Main Methods:

  • Engineered transgenic Aedes aegypti strains utilizing a female-specific indirect flight muscle promoter (Aedes aegypti Actin-4 gene).

More Related Videos

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes
07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil
17:41

Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil

Published on: January 4, 2014

Related Experiment Videos

Last Updated: Jun 16, 2026

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes
09:41

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes

Published on: September 15, 2023

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes
07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil
17:41

Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil

Published on: January 4, 2014

  • Employed either two separate transgenes or a single transgene to achieve a repressible, female-specific flightless phenotype.
  • Developed a genetic sexing system enabling male-only mosquito releases.

    • Main Results:

    • Successfully created transgenic Aedes aegypti strains exhibiting a female-specific flightless phenotype.
    • The engineered strains eliminate the need for traditional sterilization methods like irradiation.
    • Facilitates the release of eggs instead of adult mosquitoes, simplifying logistics.

    Conclusions:

    • The developed transgenic Aedes aegypti strains represent a promising new tool for mosquito control.
    • These strains enable male-only releases and egg-based deployment, enhancing control efficiency.
    • Adoption of this technology within integrated pest management strategies could lead to area-wide dengue control or elimination.