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Electroencephalographic changes associated with bromethalin toxicosis in the dog.
D C Dorman1, A J Parker, W B Buck
1Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Veterinary and Human Toxicology
|February 1, 1991
Summary
Bromethalin rodenticide poisoning in dogs causes significant electroencephalogram (EEG) abnormalities. These EEG changes, including spike patterns and voltage depression, indicate neurological dysfunction following bromethalin exposure.
Area of Science:
- Veterinary Neurology
- Toxicology
- Neurophysiology
Background:
- Bromethalin is a widely used rodenticide.
- Accidental or intentional poisoning in domestic animals, particularly dogs, can occur.
- Understanding the neurological effects of bromethalin is crucial for diagnosis and treatment.
Purpose of the Study:
- To characterize the electroencephalogram (EEG) changes associated with bromethalin toxicosis in dogs.
- To correlate EEG abnormalities with clinical signs of bromethalin poisoning.
Main Methods:
- Electroencephalogram (EEG) recordings were performed on nine dogs before and after administration of bromethalin.
- Dogs received a clinical syndrome-inducing dose of 6.25 mg bromethalin/kg orally.
- EEG data were analyzed for specific patterns and abnormalities.
Main Results:
- Clinical signs and EEG abnormalities developed 15 to 58 hours post-bromethalin ingestion.
- Common EEG findings included spike and spike-and-wave patterns (66%), high voltage slow wave activity (44%), and photoconvulsive responses (44%).
- Marked voltage depression was observed in all leads in 33% of the dogs.
Conclusions:
- Bromethalin poisoning induces distinct and significant electroencephalogram (EEG) abnormalities in dogs.
- EEG monitoring can aid in the diagnosis and assessment of neurological impairment in bromethalin toxicosis.
- The observed EEG patterns reflect the neurotoxic effects of bromethalin.