Electroencephalographic changes associated with bromethalin toxicosis in the dog
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D C Dorman1, A J Parker, W B Buck
1Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Veterinary and Human Toxicology
|February 1, 1991
Abstract:
Electroencephalogram (EEG) recordings were obtained before and during the clinical syndrome induced by a bromethalin rodenticide given to dogs. Nine dogs given 6.25 mg bromethalin/kg po developed clinical signs and EEG abnormalities 15 to 58 h postdosing. Predominant abnormal EEG changes included spike and spike-and-wave EEG patterns (66%), high voltage slow wave (HVSA, 50-150 microV, 1-6 Hz) activity (44%) photoconvulsive or photoparoxysmal irritative responses (44%), and marked voltage depression (dominant activity less than 10 microV) in all leads (33%).