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Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Cytoskeletal Coordination in Cell Migration

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

Cell Polarization by Rho Proteins

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...

Chemotaxis and Direction of Cell Migration

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

Role of Myosin in Cell Migration

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...

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Related Experiment Video

Updated: Jun 15, 2026

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

Sirt1 and cell migration.

Bor Luen Tang¹

¹Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore. bor_luen_tang@nuhs.edu.sg

Cell Adhesion & Migration

|February 25, 2010

Summary

Sirtuin 1 (SIRT1) deacetylates cortactin, a protein involved in cell movement, thereby inhibiting cancer cell migration and invasion. This finding reveals a new mechanism for SIRT1

Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

Sirtuin 1 (SIRT1) is a deacetylase enzyme regulating metabolism and stress response.
SIRT1 influences cell survival and various human pathologies, including cancer.
SIRT1 deacetylation of tumor suppressors like p53 and Rb impacts tumorigenesis.

Discussion:

Cortactin, an F-actin binding protein, is identified as a novel substrate for SIRT1.
Acetylation of cortactin by p300 and subsequent deacetylation by SIRT1 affects cell migration.
SIRT1's regulation of cell migration and invasion contributes to its role in cancer.

Key Insights:

SIRT1 directly or indirectly deacetylates cortactin.
Deacetylation of cortactin by SIRT1 retards cell migration.

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In vitro Cell Migration and Invasion Assays

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Published on: May 13, 2012

Related Experiment Videos

Last Updated: Jun 15, 2026

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

In vitro Cell Migration and Invasion Assays

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

SIRT1's modulation of cortactin impacts cancer cell invasion.

Outlook:

Further investigation into SIRT1-cortactin interactions in different cancer types.
Exploring therapeutic strategies targeting the SIRT1-cortactin pathway for cancer treatment.
Understanding the broader implications of SIRT1's non-histone substrate modifications in disease.