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Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Overview of Systemic Arteries01:11

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.
Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Capillary Beds01:20

Capillary Beds

Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.

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Updated: Jun 15, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Coupling microcirculation to systemic hemodynamics.

Daniel De Backer1, Julian A Ortiz, Diamantino Salgado

  • 1Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. ddebacke@ulb.ac.be <ddebacke@ulb.ac.be>

Current Opinion in Critical Care
|February 25, 2010
PubMed
Summary
This summary is machine-generated.

Microcirculatory abnormalities are common in critically ill patients, impacting organ failure and outcomes. Systemic hemodynamics and microvascular perfusion are loosely linked, with alterations occurring even with stable systemic parameters.

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Rapid Whole-Mount High-Resolution Imaging of Small Animal Vasculature for Quantitative Studies
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Last Updated: Jun 15, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
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Published on: June 22, 2012

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Area of Science:

  • Critical Care Medicine
  • Physiology
  • Hemodynamics

Background:

  • Microcirculatory alterations are frequently observed in critically ill patients.
  • These abnormalities are linked to poor patient outcomes.

Purpose of the Study:

  • To discuss the role of microcirculatory abnormalities in critically ill patients.
  • To explore the relationship between systemic hemodynamics and microvascular perfusion.

Main Methods:

  • Review of recent findings on microcirculation in critical illness.
  • Analysis of the dissociation between systemic and microcirculatory parameters.

Main Results:

  • Microcirculatory alterations occur in severe sepsis, heart failure, and high-risk surgery.
  • Alterations correlate with severity and outcome.
  • Microvascular perfusion can be dissociated from systemic hemodynamics, even with adequate systemic goals.

Conclusions:

  • Microvascular dysfunction is prevalent in critical illness and contributes to organ failure.
  • The relationship between systemic hemodynamics and microcirculation is not always direct.