Organizing principles of cortical layer 6
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Updated: Jun 3, 2026

Examining Local Network Processing using Multi-contact Laminar Electrode Recording
Published on: September 8, 2011
1Laboratory of Dr. W. M. Usrey, Center for Neuroscience, Division of Biological Sciences, University of California Davis, CA, USA.
Abstract:
Neurons in the deepest layer of mammalian cerebral cortex are morphologically and physiological diverse and are situated in a strategic position to modulate neuronal activity locally and in other structures. The variety of neuronal circuits within which layer 6 neurons participate differs across species and cortical regions. However even amidst this diversity, common organizational features emerge. Examination of the anatomical and physiological characteristics of different classes of layer 6 neuron, each specialized to participate in distinct circuits, provides insight into the functional contributions of layer 6 neurons toward cortical information processing.
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