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Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
Centrifugation01:05

Centrifugation

Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...

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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
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Continuous separation of cells and particles in microfluidic systems.

Andreas Lenshof1, Thomas Laurell

  • 1Dept. Measurement Technology and Industrial Electrical Engineering, Div. Nanobiotechnology, Lund University, 22100 Lund, Sweden. andreas.lenshof@elmat.lth.se

Chemical Society Reviews
|February 25, 2010
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Summary

Microfluidic technology advances enable new bioanalytical methods and cell biology studies. Recent developments focus on microfluidic cell and particle separation for lab-on-a-chip systems, impacting research and diagnostics.

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Last Updated: Jun 15, 2026

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09:45

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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Area of Science:

  • Biotechnology
  • Bioengineering
  • Cell Biology

Background:

  • Microfabrication and lab-on-a-chip technologies are advancing bioanalytics and cell biology.
  • Elastomer-based microfluidics have increased accessibility for the scientific community.
  • Microfluidic separation of cells and particles is a rapidly developing field.

Purpose of the Study:

  • To review recent developments in microfluidic technology for cell and particle separation.
  • To highlight applications in lab-on-a-chip systems for cell biology research.
  • To discuss the industrial interest in microchip-based flow cytometry for diagnostics.

Main Methods:

  • Critical review of recent scientific literature (130 references).
  • Focus on continuous flow microfluidic systems for cell and particle separation.
  • Analysis of advancements in lab-on-a-chip designs and microchip flow cytometry.

Main Results:

  • Significant progress in microfluidic devices for controlled cellular microenvironments.
  • Emerging applications in preclinical research and clinical diagnostics.
  • Development of advanced microfluidic systems for efficient cell and particle separation.

Conclusions:

  • Microfluidic technology is crucial for next-generation bioanalytics and cell studies.
  • Lab-on-a-chip systems offer controlled environments for fundamental cell biology.
  • Microchip flow cytometry shows promise for both research and clinical applications.