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Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell

Lan Xiao1, Jaladanki N Rao, Tongtong Zou

  • 1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

American Journal of Physiology. Cell Physiology
|February 26, 2010
PubMed

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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