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Updated: May 28, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Circular RNAs in Intestinal Mucosal Homeostasis and Pathologies.

Hee Kyoung Chung1, Lan Xiao1,2, Jian-Ying Wang1,2,3

  • 1Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Non-Coding RNA
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are key regulators of intestinal epithelial homeostasis and gut diseases. This review highlights their roles and potential as biomarkers and therapeutic targets.

Keywords:
IBDRNA-binding proteinsepithelium integritylong noncoding RNAsmucosal injury and repair

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Last Updated: May 28, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Laser Ablation and Intravital Microscopy to Study Intestinal Remodeling
09:42

Laser Ablation and Intravital Microscopy to Study Intestinal Remodeling

Published on: June 9, 2023

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • RNA Biology

Background:

  • The intestinal epithelium is a rapidly self-renewing tissue crucial for host-environment interaction.
  • Maintaining intestinal homeostasis involves coordinated cellular processes like proliferation, migration, and differentiation.
  • Circular RNAs (circRNAs) are emerging as vital regulators in intestinal epithelial biology and pathology.

Purpose of the Study:

  • To review the pathobiological functions and regulatory mechanisms of intestinal epithelium-enriched circRNAs.
  • To highlight specific circRNAs like circHIPK3, Cdr1as, and circPABPN1.
  • To discuss the clinical potential of circRNAs in gut diseases.

Main Methods:

  • Literature review of studies on circRNAs in intestinal epithelium.
  • Analysis of circRNA mechanisms, including interactions with microRNAs and RNA-binding proteins.
  • Focus on specific circRNAs implicated in gut homeostasis and disease.

Main Results:

  • CircRNAs are stable regulatory molecules involved in intestinal mucosa growth, regeneration, and barrier function.
  • Dysregulated circRNAs are linked to inflammatory bowel disease and malignancies.
  • Specific circRNAs (circHIPK3, Cdr1as, circPABPN1) play significant roles in intestinal epithelium.

Conclusions:

  • CircRNAs are critical players in intestinal epithelial homeostasis and disease pathogenesis.
  • CircRNAs hold promise as diagnostic biomarkers and therapeutic targets for gastrointestinal disorders.
  • Further research into circRNA mechanisms can advance clinical applications in gut health.