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S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function

Gabriela Schneider1, Anna Filipek

  • 1Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.

Amino Acids
|February 26, 2010
PubMed

Insights

The CacyBP/SIP protein, also known as S100A6 binding protein and Siah-1 interacting protein, is involved in various cellular functions including ubiquitination and proliferation. This review summarizes its properties and known cellular roles.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • CacyBP/SIP (S100A6 binding protein and Siah-1 interacting protein) was identified as a target of S100A6 and an interacting protein of Siah-1.
  • It interacts with multiple proteins including S100 family members, Skp1, tubulin, and ERK1/2.
  • CacyBP/SIP is expressed in various tissues, with particularly high levels detected in the brain.

Purpose of the Study:

  • To review the known properties of CacyBP/SIP.
  • To summarize the current understanding of CacyBP/SIP's cellular functions.
  • To consolidate findings on CacyBP/SIP's roles in biological processes.

Main Methods:

  • Literature review of studies on CacyBP/SIP.
  • Analysis of protein interaction data.
  • Examination of expression patterns and functional studies.

Main Results:

  • CacyBP/SIP exhibits diverse protein interactions.
  • Its expression is widespread, with notable abundance in neural tissues.
  • Emerging evidence suggests roles in ubiquitination, proliferation, differentiation, tumorigenesis, cytoskeletal rearrangement, and transcription regulation.

Conclusions:

  • CacyBP/SIP is a multifunctional protein with significant roles in cellular processes.
  • Further research is warranted to fully elucidate its mechanisms of action.
  • Understanding CacyBP/SIP's functions may offer insights into various diseases.

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