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Updated: Jun 15, 2026
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
Published on: July 27, 2017
S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function
Gabriela Schneider1, Anna Filipek
1Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.
Amino Acids
|February 26, 2010
Summary
The CacyBP/SIP protein, also known as S100A6 binding protein and Siah-1 interacting protein, is involved in various cellular functions including ubiquitination and proliferation. This review summarizes its properties and known cellular roles.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- CacyBP/SIP (S100A6 binding protein and Siah-1 interacting protein) was identified as a target of S100A6 and an interacting protein of Siah-1.
- It interacts with multiple proteins including S100 family members, Skp1, tubulin, and ERK1/2.
- CacyBP/SIP is expressed in various tissues, with particularly high levels detected in the brain.
Purpose of the Study:
- To review the known properties of CacyBP/SIP.
- To summarize the current understanding of CacyBP/SIP's cellular functions.
- To consolidate findings on CacyBP/SIP's roles in biological processes.
Main Methods:
- Literature review of studies on CacyBP/SIP.
- Analysis of protein interaction data.
- Examination of expression patterns and functional studies.
Main Results:
- CacyBP/SIP exhibits diverse protein interactions.
- Its expression is widespread, with notable abundance in neural tissues.
- Emerging evidence suggests roles in ubiquitination, proliferation, differentiation, tumorigenesis, cytoskeletal rearrangement, and transcription regulation.
Conclusions:
- CacyBP/SIP is a multifunctional protein with significant roles in cellular processes.
- Further research is warranted to fully elucidate its mechanisms of action.
- Understanding CacyBP/SIP's functions may offer insights into various diseases.
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