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Updated: Jun 15, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
A new dolabrane-type diterpene from Ceriops tagal
Xiao-Wei Ouyang1, Xia-Chang Wang, Qing-Xi Yue
1Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, P. R. China.
Researchers isolated a new compound, tagalsin O, and six known analogues from the Ceriops tagal mangrove. These compounds were tested for their potential to fight cervical cancer cells.
Area of Science:
- Natural Product Chemistry
- Marine Biology
- Pharmacology
Background:
- Mangrove plants, such as Ceriops tagal, are rich sources of bioactive natural products.
- Dolabrane-type diterpenes are a class of compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize novel and known compounds from Ceriops tagal.
- To evaluate the cytotoxic activity of isolated compounds against cancer cell lines.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic data (NMR, MS).
- Cytotoxicity assays using HeLa human cervical carcinoma cell line.
Main Results:
- A new dolabrane-type diterpene, tagalsin O (1), was identified.
- Six known analogues (2-7) were also isolated and characterized.
- The cytotoxic potential of the isolated compounds was evaluated against HeLa cells.
Conclusions:
- Ceriops tagal is a valuable source of structurally diverse dolabrane-type diterpenes.
- Tagalsin O and its analogues warrant further investigation for anticancer properties.
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