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Effect of a new synbiotic mixture on atopic dermatitis in infants: a randomized-controlled trial

L B van der Aa1, H S Heymans, W M van Aalderen

  • 1Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Amsterdam, The Netherlands.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|February 27, 2010
PubMed

Insights

This study found that a synbiotic mixture did not improve atopic dermatitis (AD) severity in infants. However, it did alter gut bacteria, suggesting potential benefits for IgE-associated AD in future research.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Microbiome Research

Background:

  • Clinical trials on probiotics for atopic dermatitis (AD) yield inconsistent results.
  • Synbiotics, a combination of probiotics and prebiotics, may offer improved therapeutic effects.
  • Investigating synbiotics is crucial for understanding their role in managing infant AD.

Purpose of the Study:

  • To evaluate the efficacy of a specific synbiotic mixture in reducing AD severity in infants.
  • To assess the impact of the synbiotic intervention on infant intestinal microbiota composition.

Main Methods:

  • A double-blind, placebo-controlled, multi-center trial involving 90 infants with AD (SCORAD score ≥15).
  • Infants received either a synbiotic-supplemented extensively hydrolyzed formula or a placebo formula for 12 weeks.
  • Primary outcome: change in SCORAD index; Secondary outcome: intestinal microbiota analysis.

Main Results:

  • No significant difference in overall SCORAD score improvement between synbiotic and placebo groups.
  • Synbiotic intervention successfully modulated intestinal microbiota, increasing beneficial Bifidobacteria.
  • A significant improvement in SCORAD scores was observed in the synbiotic group for infants with IgE-associated AD (P=0.04).

Conclusions:

  • The tested synbiotic mixture did not demonstrate a significant benefit for overall infant AD severity.
  • The synbiotic effectively modulated the intestinal microbiota in infants.
  • Further research is warranted to explore the potential of synbiotics in treating IgE-associated AD.
Abstract

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