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Related Concept Videos

One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
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Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

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Improving IV Insulin Administration in a Community Hospital
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Published on: June 11, 2012

Impact of computerized orders for pediatric continuous drug infusions on detecting infusion pump programming errors:

Azizeh K Sowan1, Mohamed I Gaffoor, Karen Soeken

  • 1School of Nursing, Hashemite University, Zarqa, Jordan.

Journal of Pediatric Nursing
|February 27, 2010
PubMed
Summary

Computerized orders for continuous infusions in pediatric ICUs saved nurses time but did not improve detection of infusion pump programming errors. Nurses preferred computerized orders, though errors persisted due to manual calculations.

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Area of Science:

  • Pediatric Intensive Care
  • Medication Safety
  • Health Informatics

Background:

  • Continuous infusion medications are critical in pediatric intensive care units (PICUs).
  • These infusions are associated with potentially fatal adverse events.
  • Infusion pump programming errors represent a significant safety concern.

Purpose of the Study:

  • To evaluate the impact of computerized orders versus handwritten orders on detecting infusion pump programming errors.
  • To assess the effect on the time nurses spent verifying pump settings.
  • To determine user satisfaction with computerized order entry for continuous infusions.

Main Methods:

  • A crossover design was employed to compare computerized and handwritten orders.
  • The study focused on nurses' ability to detect infusion pump programming errors.
  • Time to verify pump settings and user satisfaction were also measured.

Main Results:

  • Computerized orders significantly reduced the time required for nurses to verify pump settings.
  • However, computerized orders did not improve nurses' ability to detect infusion pump programming errors.
  • Nurses expressed a preference for using computerized orders over handwritten ones.

Conclusions:

  • While computerized orders enhance efficiency and user preference in PICUs, they do not inherently reduce infusion pump programming errors.
  • High error rates were linked to manual calculations and inconsistent implementation of computerized systems.
  • Further system improvements are needed to address persistent safety risks associated with continuous infusions.