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Diagnostic value of plasma antidiuretic hormone, electrocochleography, and glycerol test in patients with
Daizo Taguchi1, Akinobu Kakigi, Taizo Takeda
1Division of Otolaryngology, Head and Neck Surgery, Tottori University Faculty of Medicine, Tottori, Japan.
Insights
Diagnosing endolymphatic hydrops (ELH) is improved by using plasma antidiuretic hormone (p-ADH) levels, electrocochleogram (ECoG), and the glycerol test together. Combining these tests increases diagnostic accuracy for ELH.
Area of Science:
- Otolaryngology
- Nephrology
- Neurology
Background:
- Endolymphatic hydrops (ELH) is a condition affecting the inner ear.
- Accurate diagnosis of ELH is crucial for effective treatment.
- Current diagnostic methods may have limitations in sensitivity and specificity.
Purpose of the Study:
- To evaluate the diagnostic utility of plasma antidiuretic hormone (p-ADH) levels.
- To assess the role of electrocochleogram (ECoG) in ELH detection.
- To investigate the effectiveness of the glycerol test for diagnosing ELH.
Main Methods:
- Sixty patients with various forms of ELH, including Ménière's disease, were included.
- Measurements of p-ADH levels, ECoG, and glycerol test results were obtained within a four-week period.
- Comparative analysis of the three diagnostic tests was performed.
Main Results:
- Thirteen patients (21.7%) tested positive across all three diagnostic methods.
- A significant majority of patients (58/60, 96.7%) showed positive results in at least one test.
- Only two patients (3.3%) yielded negative results for all evaluated tests.
Conclusions:
- Plasma antidiuretic hormone (p-ADH) levels, ECoG, and the glycerol test exhibit distinct selectivities for detecting ELH.
- The combination of these three tests offers a more comprehensive approach to ELH diagnosis.
- Utilizing all three diagnostic modalities is recommended for improved diagnostic accuracy in ELH.
Objective:
To investigate the relationship between the plasma antidiuretic hormone (p-ADH) level, electrocochleogram (ECoG), and the glycerol test in patients with endolymphatic hydrops (ELH).
Patients And Methods:
The subjects were 60 patients, including 51 with Ménière's disease (except for cochlear Ménière's disease), 7 with delayed ELH, and 2 with syphilitic ELH. The time period for measurements of the p-ADH level, ECoG and the glycerol test was within 4 weeks.
Results:
13 patients showed positive results for all tests. 58 patients showed positive results for at least one of three tests. Only 2 patients showed negative results for all tests.
Conclusion:
The p-ADH level, ECoG and the glycerol test show different selectivity of ELH detection. It is useful to perform all three tests to diagnose ELH.
