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A Murine Model of Hemodialysis Access-Related Hand Dysfunction
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Better nephrology for mice--and man.

Matthew D Breyer1, Zhonghua Qi

  • 1Biotechnology Discovery Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA. breyer_matthew@lilly.com

Kidney International
|February 27, 2010
PubMed
Summary

Creatinine-based glomerular filtration rate estimation has artifacts. In mice, creatinine secretion significantly impacts clearance more than in humans, questioning its use for measuring kidney function in this model.

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Area of Science:

  • Nephrology
  • Animal Models
  • Biomarker Analysis

Background:

  • Glomerular filtration rate (GFR) is a key indicator of kidney function.
  • Creatinine is a commonly used endogenous biomarker for estimating GFR in clinical practice.
  • However, creatinine-based GFR estimation is subject to known artifacts, including tubular secretion.

Discussion:

  • This study investigates the impact of creatinine secretion on creatinine clearance (CrCl) in mice.
  • Findings indicate that creatinine secretion plays a more substantial role in mice than in humans.
  • This highlights potential limitations of using creatinine for accurate GFR assessment in murine models.

Key Insights:

  • Creatinine secretion significantly overestimates creatinine clearance in mice.
  • The magnitude of this artifact is greater in mice compared to humans.
  • This challenges the reliability of standard creatinine-based GFR measurements in preclinical mouse studies.

Outlook:

  • Re-evaluation of current methods for GFR measurement in mice is warranted.
  • Development of alternative or adjusted biomarkers for GFR estimation in preclinical research is needed.
  • Improved understanding of renal handling of creatinine in mice may refine experimental design.

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