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Related Concept Videos

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Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
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Published on: December 22, 2023

Gastroschisis: preterm or term delivery?

Henrique Soares1, Ana Silva, Gustavo Rocha

  • 1Neonatology Department, São João Hospital and Porto Medical School - Porto/Portugal.

Clinics (Sao Paulo, Brazil)
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

This study found that premature delivery does not accelerate full enteral feeding in newborns with gastroschisis. Anticipating delivery did not show benefits for feeding outcomes or hospital stay.

Keywords:
Enteral feedingGastroschisisNewbornPerinatal outcomePreterm

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Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Gastroenterology

Background:

  • Gastroschisis is a congenital abdominal wall defect requiring surgical repair.
  • Nutritional support, specifically enteral feeding, is crucial for neonatal outcomes.
  • The optimal timing of delivery for fetuses diagnosed with gastroschisis remains a topic of clinical interest.

Purpose of the Study:

  • To evaluate the association between prematurity and the time to achieve full enteral feeding in newborns with gastroschisis.
  • To analyze the impact of delivery mode, birth weight, and surgical approach on feeding progression and hospital stay.

Main Methods:

  • Retrospective review of medical records for newborns with gastroschisis (1997-2007).
  • Comparison of outcomes between infants delivered before 37 weeks (preterm) and after 37 weeks (term).
  • Analysis of gestational age, birth weight, delivery mode, time to full enteral feeding, and length of hospital stay.

Main Results:

  • Premature infants (Group A) showed a trend towards longer time to full enteral feeding (30.1 days) compared to term infants (Group B, 17.0 days), though not statistically significant (p=0.09).
  • No significant differences in time to full enteral feeding were observed based on low birth weight (<2500g) or mode of delivery.
  • Infants with birth weight over 2500g had a shorter hospital stay (22.9 days) compared to those under 2500g (35.7 days).

Conclusions:

  • The findings do not support the practice of anticipating the delivery of fetuses with gastroschisis to expedite enteral feeding.
  • Gestational age at delivery does not appear to be a primary determinant for earlier achievement of full enteral feeding in this population.
  • Birth weight may influence length of hospital stay, but not necessarily feeding progression directly.