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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

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Updated: Jun 15, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

Pain in Parkinson's disease.

¹Department of Neurology, Columbia University, New York, New York, USA. bford@neuro.columbia.edu

Movement Disorders : Official Journal of the Movement Disorder Society

|February 27, 2010

Summary

Parkinson's disease (PD) significantly impacts patients through various pain syndromes, affecting approximately 40%. This review details pain classification, diagnosis, and treatment strategies for PD.

Area of Science:

Neurology
Pain Medicine

Background:

Parkinson's disease (PD) is primarily known for motor and cognitive deficits.
Pain affects around 40% of PD patients, often severely impacting quality of life.
Pain in PD can be a primary feature, overshadowing motor symptoms in some cases.

Purpose of the Study:

To review the diverse pain syndromes associated with Parkinson's disease.
To present a classification of pain types experienced by PD patients.
To outline a diagnostic and treatment framework for painful PD.

Main Methods:

Review of descriptive surveys on non-motor symptoms in PD.
Analysis of classifications for painful sensations in PD patients.
Synthesis of current understanding of pain mechanisms in PD.

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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

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Published on: October 14, 2021

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Last Updated: Jun 15, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Main Results:

Pain in PD is categorized into musculoskeletal, radicular/neuropathic, dystonia-related, akathitic, and central parkinsonian pain.
A significant minority of patients experience intractable pain that dominates their symptoms.
Recent insights into neurophysiological mechanisms of pain in PD have emerged.

Conclusions:

Pain is a prevalent and significant non-motor symptom in Parkinson's disease.
A structured approach to diagnosing and managing pain is crucial for PD patients.
Understanding the neurobiology of pain in PD is key to developing effective therapies.