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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Bacterial RNA Polymerase00:43

Bacterial RNA Polymerase

Unlike eukaryotes, bacteria use a single RNA Polymerase (RNAP) to transcribe all genes. The different subunits of bacterial RNAPhave distinct functions. The multisubunit structure of the bacterial RNAP helps the enzyme to maintain catalytic function, facilitate assembly, interact with DNA and RNA, and self-regulate its activity.
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...

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Related Experiment Video

Updated: Jun 15, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

The transcriptome of Mycobacterium tuberculosis.

Rachel Haller1, Meghann Kennedy, Nick Arnold

  • 1Department of Biology, Seattle University, 901 12th Ave., Seattle, WA, USA.

Applied Microbiology and Biotechnology
|February 27, 2010
PubMed
Summary

This review synthesizes current knowledge of the Mycobacterium tuberculosis transcriptome, integrating experimental and computational data. Consolidating these findings aims to accelerate future research into this important bacterial pathogen.

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Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
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Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis

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Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies
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Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies

Published on: September 3, 2012

Related Experiment Videos

Last Updated: Jun 15, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies
07:56

Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies

Published on: September 3, 2012

Area of Science:

  • Microbiology
  • Genomics
  • Molecular Biology

Background:

  • The Mycobacterium tuberculosis transcriptome is complex and crucial for understanding bacterial survival and pathogenesis.
  • Previous research has generated significant, yet fragmented, data on gene expression patterns.

Purpose of the Study:

  • To consolidate and review existing knowledge of the Mycobacterium tuberculosis transcriptome.
  • To integrate experimentally verified findings with computationally derived predictions.
  • To provide a foundation for future research on Mycobacterium tuberculosis and other prokaryotes.

Main Methods:

  • Comprehensive literature review of published studies.
  • Comparative analysis of independent research findings.
  • Synthesis of experimental and computational transcriptome data.

Main Results:

  • A catalog of experimentally verified and computationally predicted Mycobacterium tuberculosis transcripts.
  • Identification of common themes and discrepancies across independent studies.
  • Enhanced accessibility of integrated transcriptome data.

Conclusions:

  • Consolidating Mycobacterium tuberculosis transcriptome data facilitates a clearer understanding of its gene expression.
  • Improved data accessibility is key to catalyzing new discoveries in tuberculosis research.
  • The approach offers insights for characterizing transcriptomes of other prokaryotic organisms.