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Updated: Nov 19, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
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Thrombocytosis during Stable State Predicts Mortality in Bronchiectasis.

Stefano Aliberti1,2, Giovanni Sotgiu3, Andrea Gramegna1,2

  • 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, UO Pneumologia, Milan, Italy.

Annals of the American Thoracic Society
|January 28, 2021
PubMed
Summary

Thrombocytosis, or high platelet count, is linked to increased disease severity and worse outcomes in adults with bronchiectasis. This finding highlights platelets as a valuable biomarker for assessing bronchiectasis progression and patient prognosis.

Keywords:
bronchiectasismortalityplatelets

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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Clinical Research

Background:

  • Platelets are recognized inflammatory mediators in respiratory diseases.
  • The specific role of platelets in bronchiectasis remains underexplored.
  • Thrombocytosis may indicate underlying inflammation and disease severity.

Purpose of the Study:

  • To investigate the association between thrombocytosis and bronchiectasis severity.
  • To determine if thrombocytosis predicts worse clinical outcomes in patients with bronchiectasis.
  • To evaluate platelets as a potential biomarker in bronchiectasis management.

Main Methods:

  • A multicenter study enrolled 1,771 adult patients with bronchiectasis.
  • Platelet counts were assessed during stable disease state.
  • Logistic regression analysis was used to assess outcomes, adjusting for confounding variables.

Main Results:

  • 7.7% of patients presented with thrombocytosis.
  • Thrombocytosis was significantly associated with higher disease severity, poorer quality of life, and increased exacerbations and hospitalizations.
  • Patients with thrombocytosis had significantly higher 3-year and 5-year all-cause mortality rates.

Conclusions:

  • Thrombocytosis in stable bronchiectasis is a significant indicator of disease severity.
  • Elevated platelet counts are associated with increased hospitalizations due to exacerbations and higher mortality.
  • Platelets serve as a cost-effective and easily assessable biomarker for predicting outcomes in bronchiectasis.