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Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
Dental adhesives with bioactive and on-demand bactericidal properties
Ken Welch1, Yanling Cai, Håkan Engqvist
1Uppsala University, Sweden. ken.welch@angstrom.uu.se
Summary
This study introduces a novel dental adhesive with titania nanoparticles (NPs) that promotes bioactivity and offers on-demand bacterial inhibition via UV-A light, potentially reducing secondary caries and infections.
Area of Science:
- Biomaterials Science
- Dental Materials
- Nanotechnology
Background:
- Dental restorations require materials that promote healing and prevent bacterial contamination.
- Current materials often face challenges with secondary caries and interfacial gap formation.
- Developing bioactive and antimicrobial dental adhesives is a key research area.
Purpose of the Study:
- To evaluate a new dental adhesive concept incorporating crystalline titania nanoparticles (NPs) for enhanced interfacial bonding and long-term bacteria inhibition.
- To assess the bioactivity, mechanical bonding strength, and photocatalytic bactericidal properties of these novel adhesives.
- To determine the efficacy of UV-A irradiation for on-demand bacterial elimination.
Main Methods:
- Dental adhesives with varying wt% of titania NPs were prepared.
- Bioactivity was assessed by observing spontaneous hydroxylapatite formation in simulated body fluid.
- Mechanical bonding strength was tested against a hydroxyapatite (HA) tooth model.
- Photocatalytic bactericidal activity against Staphylococcus epidermidis was evaluated under UV-A irradiation.
Main Results:
- Adhesives with 20wt% NPs demonstrated bioactivity, enhanced by chemical etching.
- Mechanical bonding strength remained unaffected up to 30wt% NPs.
- Efficient elimination of Staphylococcus epidermidis was achieved with a UV-A dose of 4.5J/cm², significantly below safe limits.
Conclusions:
- The developed dental adhesives exhibit both bioactivity and on-demand bactericidal effects.
- These materials hold potential for reducing secondary caries through remineralization.
- On-demand UV-A irradiation offers a method for preventing bacterial infections at the restoration interface.
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