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Daily variations in concentration of vasoactive intestinal polypeptide immunoreactivity in discrete brain areas of
1Département de Médecine Expérimentale, INSERM U 52-CNRS URA 1195, Université Claude Bernard, Lyon, France.
Brain Research
|January 4, 1991
Abstract:
The concentration of VIP-like immunoreactivity (VIP-LI) was determined by radioimmunoassay at various times of the day in 11 discrete brain areas and in the antehypophysis of rats maintained on a regular 12 h/12 h light-dark cycle. In the suprachiasmatic and periventricular nuclei the VIP-LI increased during the dark period and decreased during the subsequent light period. In addition, the VIP-LI exhibited complex variations in the locus coeruleus, the periaqueductal gray matter and the paraventricular nucleus, but did not change in the other areas investigated.