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Related Experiment Videos

Miconazole corneal toxicity.

G W Zaidman1

  • 1Department of Ophthalmology, Westchester County Medical Center, New York Medical College, Valhalla 10595.

Cornea
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Miconazole eye drops can cause corneal toxicity, presenting as epithelial vesicles and punctate keratitis after surgery for Acanthamoeba keratitis. Discontinuation of miconazole resolved these adverse ocular effects.

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Area of Science:

  • Ophthalmology
  • Corneal Disease
  • Ocular Toxicology

Background:

  • Acanthamoeba keratitis is a severe microbial infection of the cornea.
  • Penetrating keratoplasty is a surgical option for managing corneal damage from Acanthamoeba keratitis.
  • Topical antifungals are used postoperatively to prevent or treat residual infection.

Observation:

  • A patient developed corneal toxicity following penetrating keratoplasty for Acanthamoeba keratitis.
  • The patient was treated with topical miconazole postoperatively.
  • Ocular toxicity manifested as pinpoint vesicular elevations in the corneal epithelium and superficial punctate keratitis.

Findings:

  • Miconazole administration led to characteristic corneal epithelial changes.
  • Cessation of miconazole treatment resulted in the resolution of the observed corneal toxicity.

Related Experiment Videos

  • This case highlights a specific pattern of miconazole-induced corneal epithelial toxicity.

    • Implications:

    • Clinicians should be aware of potential miconazole corneal toxicity in post-keratoplasty patients.
    • Prompt recognition and discontinuation of miconazole may prevent persistent ocular surface disease.
    • This finding contributes to understanding drug-induced ocular surface complications in corneal transplantation.