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The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
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Urinary Bladder01:23

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Related Experiment Video

Updated: Jun 15, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Detrusor overactivity: an overview.

Kiran Ashok1, Alex Wang

  • 1Department of Urogynecology, Chang-Gung Memorial Hospital, Linkou, Taiwan. drkirana@gmail.com

Archives of Gynecology and Obstetrics
|March 2, 2010
PubMed
Summary
This summary is machine-generated.

Detrusor overactivity (DO) significantly impacts women's quality of life. Understanding its causes is crucial for selecting effective treatments to improve patient outcomes.

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Last Updated: Jun 15, 2026

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03:26

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A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
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07:42

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Area of Science:

  • Urology
  • Gynecology
  • Female Pelvic Medicine

Background:

  • Detrusor overactivity (DO) is a prevalent condition affecting women's quality of life (QOL).
  • De novo DO, a consequence of anti-incontinence surgery using meshes, is an emerging concern impacting postoperative QOL.
  • The pathophysiology of DO involves complex changes in the urothelium, sub-urothelium, and detrusor muscle.

Purpose of the Study:

  • To systematically review recent literature on detrusor overactivity (DO).
  • To analyze the pathophysiology and management strategies for DO, particularly de novo DO.
  • To emphasize the importance of understanding DO causation for effective patient management.

Main Methods:

  • A systematic review of English language literature was performed.
  • Publications from the last 7 years were analyzed using data from Pubmed.
  • The review focused on the pathophysiology and treatment of DO.

Main Results:

  • DO has multifactorial causes, potentially involving urothelial and detrusor muscle pathology.
  • A range of treatments exist, from lifestyle changes to minimally invasive surgery.
  • Effective management requires a thorough understanding of the underlying pathophysiological processes.

Conclusions:

  • Understanding the pathophysiology of DO is essential for selecting appropriate treatments.
  • Physicians must carefully choose and apply treatment modalities to enhance patient QOL.
  • Addressing DO, including de novo DO, is critical for improving women's health outcomes.