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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Polymer Classification: Architecture01:14

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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...

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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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Published on: August 6, 2019

DNA polyplexes formed using PEGylated biodegradable hyperbranched polymers.

Lei Tao1, William C Chou, Beng H Tan

  • 1Centre for Advanced Macromolecular Design (CAMD), School of Chemical Sciences and Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.

Macromolecular Bioscience
|March 2, 2010
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel PEGylated biodegradable hyperbranched polymer. This new material effectively binds DNA and reduces toxicity, offering potential for advanced biomedical applications.

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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Nanotechnology

Background:

  • Development of safe and effective non-viral gene delivery vectors is crucial.
  • Hyperbranched polymers offer unique structural advantages for drug and gene delivery.
  • Biodegradable polymers are desirable for minimizing long-term accumulation and toxicity.

Purpose of the Study:

  • To synthesize and characterize a novel PEGylated biodegradable hyperbranched polymer.
  • To evaluate the polymer's DNA binding efficiency and electrostatic interactions.
  • To assess the polymer's toxicity profile and its reduction under specific conditions.

Main Methods:

  • Synthesis of PEGylated biodegradable hyperbranched poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) using a disulfide-based dimethacrylate (DSDMA) crosslinker.
  • Zeta potential measurements to confirm surface charge masking by PEGylation.
  • Analysis of polymer structure and cleavage under reducing conditions.
  • DNA binding assays to evaluate complex formation via electrostatic interactions.

Main Results:

  • Successful synthesis of PEGylated hyperbranched polymers with masked positive charges.
  • Demonstrated efficient DNA binding through electrostatic interactions.
  • Confirmation of polymer biodegradability and reduced toxicity of resulting oligomers under reducing conditions.

Conclusions:

  • The novel PEGylated biodegradable hyperbranched polymer exhibits efficient DNA complexation.
  • Surface PEGylation effectively reduces polymer toxicity.
  • The polymer's biodegradability and reduced toxicity make it a promising candidate for gene delivery systems.