Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ordered micro-nano structures: synergistic integration of microneedles and photonic crystals for advanced biomedical systems.

Journal of materials chemistry. B·2026

Same author

Computational-Aided Mutagenesis of Lipase CRL1 with Promoted Stability and Activity for Biosynthesis of Vitamin E Succinate.

Journal of agricultural and food chemistry·2026

Same author

A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Bioinspired wearable polymer microneedle patches: pioneering diabetic wound therapy for the horizon.

RSC advances·2025

Same author

Nanoengineered Enzyme Immobilization: Toward Biomedical, Orthopedic, and Biofuel Applications.

ACS omega·2025

Same author

Structural Design Strategies for Advancing Sensing on Wearable Meta-Microneedle Bandages.

ACS sensors·2025

Same journal

A Novel Chitosan-Gelatin Scaffold and Cell Spray Therapy for Treating Limbal Stem Cell Deficiency.

Macromolecular bioscience·2026

Same journal

Electroconductive Soft Microcarriers for Suspension Culture of Skeletal Muscle Cells.

Macromolecular bioscience·2026

Same journal

Dual-Responsive Chitosan-Grafted PNIPAAm Hydrogel Eye Drop Incorporating Insulin-Imprinted Microgels for Dry Eye Syndrome Treatment.

Macromolecular bioscience·2026

Same journal

Levan Inspired Hybrid Composites Materials: Bridging Natural Polysaccharides with Biomedical Technology.

Macromolecular bioscience·2026

Same journal

Anion-Specific Mechanisms in Fibrinogen Self-Assembly: Contrasting Effects of Phosphates and Chlorides in Nanofiber Formation.

Macromolecular bioscience·2026

Same journal

Photopolymerization Strategies for Macromolecular Network Engineering in Biomaterials.

Macromolecular bioscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy.

Xinran Chen¹, Kaiwen Zhou¹, Xin Li¹

¹Jiangsu Provincial University Key Laboratory of Green Biomanufacturing for Pharmaceuticals, College of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.

Macromolecular Bioscience

|June 24, 2026

Summary

This summary is machine-generated.

AI-assisted smart microneedle (MN) systems offer advanced wound management solutions. These systems integrate sensing, drug delivery, and AI for intelligent, personalized wound care, overcoming limitations of traditional methods.

Keywords:

artificial intelligence closed‐loop regulation drug delivery microneedle systems wearable sensing wound healing

More Related Videos

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Related Experiment Videos

Last Updated: Jun 25, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Area of Science:

Biomedical Engineering
Materials Science
Artificial Intelligence

Background:

Skin damage presents a significant clinical challenge in wound healing.
Traditional wound care lacks dynamic monitoring and regulation of the wound microenvironment.
Smart microneedle (MN) systems offer minimally invasive access for sensing and localized drug delivery.

Purpose of the Study:

To review recent advances in AI-assisted smart MN systems for advanced wound management.
To explore material innovation, structural engineering, fabrication, and multifunctional integration of these systems.
To highlight emerging applications and future opportunities in intelligent wound care.

Main Methods:

Review of recent literature on AI-assisted smart MN systems.
Analysis of material innovations and MN structural engineering.
Examination of fabrication technologies and multifunctional integration.

Main Results:

AI-assisted smart MN systems enable localized drug delivery and biochemical sensing.
Emerging applications include therapeutic delivery, antibacterial intervention, and wearable sensing.
AI-driven closed-loop regulation is a key development for personalized wound management.

Conclusions:

AI-assisted smart MN systems represent a significant advancement in wound management.
Integration of sensing, therapy, and AI is crucial for effective closed-loop systems.
Future opportunities lie in developing intelligent, personalized, and data-driven wound care solutions.