AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy

Area of Science:

• Biomedical Engineering
• Materials Science
• Artificial Intelligence

Background:

• Skin damage presents a significant clinical challenge in wound healing.
• Traditional wound care lacks dynamic monitoring and regulation of the wound microenvironment.
• Smart microneedle (MN) systems offer minimally invasive access for sensing and localized drug delivery.

Purpose of the Study:

• To review recent advances in AI-assisted smart MN systems for advanced wound management.
• To explore material innovation, structural engineering, fabrication, and multifunctional integration of these systems.
• To highlight emerging applications and future opportunities in intelligent wound care.

Main Methods:

• Review of recent literature on AI-assisted smart MN systems.
• Analysis of material innovations and MN structural engineering.
• Examination of fabrication technologies and multifunctional integration.

Main Results:

• AI-assisted smart MN systems enable localized drug delivery and biochemical sensing.
• Emerging applications include therapeutic delivery, antibacterial intervention, and wearable sensing.
• AI-driven closed-loop regulation is a key development for personalized wound management.

Conclusions:

• AI-assisted smart MN systems represent a significant advancement in wound management.
• Integration of sensing, therapy, and AI is crucial for effective closed-loop systems.
• Future opportunities lie in developing intelligent, personalized, and data-driven wound care solutions.