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Related Experiment Video

Updated: May 8, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.

Yuanchao Liu1, Xiujuan Hu1, Shengqun Shi2

  • 1Department of Physics, City University of Hong Kong, Kowloon, Hong Kong SAR, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 7, 2026
PubMed
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This summary is machine-generated.

This study introduces a novel microneedle device for rapid interstitial fluid (ISF) sampling, enabling real-time health monitoring. The cost-effective, AI-assisted platform offers accurate molecular and elemental analysis for point-of-care applications.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Frequent blood testing is invasive and impractical for real-time health monitoring.
  • Current microneedle platforms for interstitial fluid (ISF) sampling are complex, inefficient, and lack multiplexing capabilities.
  • There is a need for user-friendly, rapid, and cost-effective devices for ISF analysis.

Purpose of the Study:

  • To develop a portable, dual-button microneedle device for rapid ISF sampling.
  • To integrate multimodal laser sensing for simultaneous molecular and elemental analysis.
  • To enhance data interpretation using artificial intelligence (AI) for comprehensive health assessment.

Main Methods:

  • A disposable microneedle device with hollow microneedles and microfluidic channels for ISF sampling within 1 minute.
Keywords:
3D printingartificial intelligencemicrofluidicsmicroneedlessurface‐enhanced Raman spectroscopy

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Last Updated: May 8, 2026

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  • Development of a sensing module using gold nanocubes and MXene for enhanced laser spectroscopy.
  • AI-assisted data processing for spectral data interpretation.

    • Main Results:

    • The device demonstrated user-friendly operation and rapid ISF sampling (< 1 min).
    • The sensing module provided signal enhancement for molecular and elemental analysis via laser spectroscopy.
    • In vitro and in vivo studies showed promising performance with accuracies exceeding 88%.

    Conclusions:

    • The developed microneedle device is user-friendly, rapid, cost-effective, and capable of multiplexed analysis.
    • This technology bridges advanced laser spectroscopy with point-of-care applications.
    • The device shows significant potential for clinical translation in real-time health monitoring.