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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Updated: Jun 15, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Inflammatory bowel disease.

Arthur Kaser1, Sebastian Zeissig, Richard S Blumberg

  • 1Department of Medicine II, Medical University Innsbruck, Austria.

Annual Review of Immunology
|March 3, 2010
PubMed
Summary
This summary is machine-generated.

Investigating immune responses, genetics, and gut microbiota in animal models offers new insights into inflammatory bowel disease (IBD) pathogenesis. Understanding these complex interactions aids in developing targeted biologic therapies for IBD.

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Investigating Intestinal Inflammation in DSS-induced Model of IBD

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Area of Science:

  • Immunology
  • Gastroenterology
  • Microbiology

Background:

  • Inflammatory bowel disease (IBD) research is rapidly advancing.
  • Insights are driven by immunologic studies in animal models of intestinal inflammation.
  • Complex genetic traits and culture-independent microbiota analyses are key.

Purpose of the Study:

  • To review the interplay between microbiota, host immunity, and environmental factors in IBD pathogenesis.
  • To explore how these interactions are understood through genetic and microbiological investigations.
  • To identify potential therapeutic targets from biologic therapies for IBD.

Main Methods:

  • Review of immunologic investigations in animal models of intestinal inflammation.
  • Analysis of genetic studies on complex inherited traits related to IBD.
  • Examination of culture-independent methods for intestinal microbiota composition.
  • Evaluation of lessons from IBD-directed biologic therapies.

Main Results:

  • Deeper understanding of the genetically determined interplay between commensal microbiota, intestinal epithelial cells, and the immune system.
  • Identification of environmental factors influencing this interplay in IBD pathogenesis.
  • Insights into pathways central to human IBD pathogenesis.

Conclusions:

  • Advances in immunology, genetics, and microbiota research are crucial for understanding IBD.
  • The complex interplay of host-microbe-environment interactions is central to IBD pathogenesis.
  • Biologic therapies offer valuable insights into disease pathways and potential treatments for IBD.