Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventing post-denosumab bone loss with zoledronate: a 2-year randomized trial in post-menopausal women without and with pre-exposure to bisphosphonates.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Publisher Correction: Probiotic Supplementation and Bone Health Parameters in Adults: A Systematic Review and Meta-Analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Health-related quality of life instruments for older persons with osteoporosis: a WHO-BOHEG systematic review of measurement properties for use in clinical trials and routine practice.

Age and ageing·2026
Same author

Albumin-adjusted ("corrected") calcium should no longer be reported: a position statement from the Joint IOF Working Group and IFCC Committee on Bone Metabolism and EFLM Committee on CKD.

Clinical chemistry and laboratory medicine·2026
Same author

Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.

Aging clinical and experimental research·2026
Same author

"Build better bones": development, launch, and future directions of a multilingual, user-centered website for osteoporosis management.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

[Erythema multiforme : target deciphering].

Revue medicale suisse·2026
See all related articles

Related Experiment Videos

[Osteoporosis].

Brigitte Uebelhart1, René Rizzoli

  • 1Service des maladies osseuses, Département de réhabilitation et gériatrie, HUG et Faculté de médecine de Genève, 1211 Genève 14.

Revue Medicale Suisse
|March 4, 2010
PubMed
Summary
This summary is machine-generated.

FRAX tool assesses fracture risk. Vitamin D, denosumab, zoledronate, and teriparatide offer benefits for osteoporosis and cancer treatment, while vertebroplasty is not a primary choice for vertebral fractures.

Related Experiment Videos

Area of Science:

  • Orthopedics and Endocrinology
  • Pharmacology and Therapeutics

Context:

  • Osteoporosis management requires effective fracture risk assessment and treatment strategies.
  • Current treatments include bisphosphonates, vitamin D, and newer agents like denosumab, zoledronate, and teriparatide.
  • Glucocorticoid-induced osteoporosis presents unique treatment challenges.

Purpose:

  • To review current evidence on fracture risk evaluation and management strategies for osteoporosis.
  • To compare the efficacy of different osteoporosis treatments, including bisphosphonates, denosumab, zoledronate, and teriparatide.
  • To discuss the role of vertebroplasty and potential adverse events associated with osteoporosis therapies.

Summary:

  • The FRAX tool aids in fracture risk assessment. Vitamin D supplementation reduces falls and mortality.
  • Denosumab is effective for postmenopausal osteoporosis and in certain cancer therapies.
  • Zoledronate and teriparatide show superior efficacy over risedronate and alendronate for glucocorticoid-induced osteoporosis, with combination therapy showing promise.
  • Vertebroplasty is not a first-line treatment for symptomatic osteoporotic vertebral fractures.
  • Osteonecrosis of the jaw and subtrochanteric fractures are potential risks with bisphosphonate therapy.

Impact:

  • Provides a comprehensive overview of current osteoporosis management options.
  • Highlights the comparative effectiveness of various pharmacologic agents.
  • Informs clinical decision-making regarding treatment selection and risk-benefit assessment.
  • Emphasizes the importance of considering potential adverse events in long-term osteoporosis treatment.