Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...

Chemical and Solubility Equilibria

Chemical and Solubility Equilibria

The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place, the Gibbs energy change must be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026

Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025

Same author

An operating system for executing applications on quantum network nodes.

Nature·2025

Same author

Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

Physical review letters·2023

Same author

Size and environment: The effect of phonon localization on micro-Brillouin imaging.

Biomaterials advances·2023

Same author

Interpenetrating gels in binary suspensions of DNA nanostars.

The Journal of chemical physics·2022

Same journal

The Role of Functional Groups in Substituted Benzoic Acids Used as Dopants in Liquid Crystal Mixtures on the Nematic-Isotropic Transitions.

The journal of physical chemistry. B·2026

Same journal

Hyperfine Coupling Quantifies Hole Delocalization in Triarylamine Radical Cations of D-χ-A Molecules.

The journal of physical chemistry. B·2026

Same journal

A Solvatochromic-Chemometric Framework to Resolve Subtle Polarity Microenvironment Differences in Cycloalkanes Driven by Molecular Conformation and Substituent Effects: A Proof-Of-Concept for Advanced Aviation Fuel Design.

The journal of physical chemistry. B·2026

Same journal

Selective Effects of Backbone Cyclization and Disulfide Bonding as Global Covalent Constraints on the Conformational Ensemble of Sunflower Trypsin Inhibitor-1.

The journal of physical chemistry. B·2026

Same journal

Europium Coordination Structure in Peptide Complexes Resolved with Simulation and X-ray Absorption Spectroscopy.

The journal of physical chemistry. B·2026

Same journal

Competitive Coordination and Structural Evolution of Phenylalanine-Mg<sup>2+</sup> Complexes in Microaqueous Environments: Insights from DFT and Molecular Dynamics Simulations.

The journal of physical chemistry. B·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 15, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Modeling the crossover between chemically and diffusion-controlled irreversible aggregation in a small-functionality

S Corezzi¹, D Fioretto, C De Michele

¹Dipartimento di Fisica, Università di Perugia, Via A. Pascoli, I-06100 Perugia, Italy. silvia.corezzi@fisica.unipg.it

The Journal of Physical Chemistry. B

|March 4, 2010

Summary

This summary is machine-generated.

Numerical simulations reveal that cluster diffusion significantly impacts late-stage aggregation kinetics in gel formation. A single time scale, related to diffusion, accurately describes the reaction

More Related Videos

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Related Experiment Videos

Last Updated: Jun 15, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Area of Science:

Physical Chemistry
Polymer Science
Materials Science

Background:

Irreversible aggregation processes are fundamental in polymer science and materials science.
Understanding the kinetics of gel formation is crucial for controlling material properties.

Purpose of the Study:

To investigate the role of cluster diffusion in the late stages of gel-forming aggregation.
To identify the key factors controlling the transition from chemically controlled to diffusion-controlled aggregation.

Main Methods:

Analysis of realistic numerical simulations of a gel-forming irreversible aggregation process.
Scrutinizing simulation data to understand the origin of the aggregation crossover.

Main Results:

Cluster diffusion plays a critical role in controlling late-stage aggregation kinetics.
The crossover from chemically to diffusion-controlled aggregation occurs after percolation, when only small clusters remain.
A single time scale, related to average diffusion time, accurately describes the reaction evolution.

Conclusions:

Cluster diffusion is a key determinant of aggregation kinetics beyond percolation.
The late stages of aggregation are governed by diffusion, even after significant network formation.
A simplified model based on diffusion time can effectively describe the overall aggregation process.