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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Pseudoneoplastic mimics of prostate and bladder carcinomas
Omar Hameed1, Peter A Humphrey
1Department of Pathology, University of Alabama at Birmingham, 35294-6823, USA. ohameed@uab.edu
Archives of Pathology & Laboratory Medicine
|March 4, 2010
Summary
This study reviews pseudoneoplastic lesions in the prostate and bladder that mimic cancer. Recognizing these mimics is crucial for accurate diagnosis and avoiding misdiagnosis of prostatic carcinoma and bladder neoplasms.
Area of Science:
- Uropathology
- Surgical Pathology
- Oncology
Background:
- Differential diagnosis of prostatic carcinoma and bladder neoplasms includes histologic mimics.
- Misdiagnosis can occur if these mimics are not recognized.
Purpose of the Study:
- To discuss pseudoneoplastic lesions of the prostate and bladder.
- Focus on distinguishing histopathologic features to differentiate from malignancy.
- Highlight potential diagnostic pitfalls.
Main Methods:
- Review of relevant published literature.
- Incorporation of authors' clinical experience.
Main Results:
- Prostatic pseudoneoplasms include atrophy, adenosis, basal cell hyperplasia, crowded benign glands, and seminal vesicle epithelium.
- These can mimic lower-grade prostatic adenocarcinoma or higher-grade Gleason adenocarcinoma.
- Bladder pseudoneoplasms include reactive urothelial atypia, polypoid/papillary cystitis, pseudocarcinomatous hyperplasia, von Brunn nests, and nephrogenic adenoma.
- These mimic urothelial carcinoma in situ, papillary neoplasms, or invasive urothelial carcinoma.
Conclusions:
- Diagnostic awareness of pseudoneoplastic lesions is critical.
- Understanding histomorphologic and immunohistochemical features prevents false-positive diagnoses.
- Accurate identification of pseudoneoplasms avoids unnecessary treatment for malignancy.
