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Swine-origin influenza A (H1N1) in Indian children

A Saha1, N Jha, N K Dubey

  • 1Department of Pediatrics, Postgraduate Institute of Medical Education & Research and Associated Dr Ram Manohar Lohia Hospital, New Delhi, India. drabhijeetsaha@yahoo.com

Annals of Tropical Paediatrics
|March 4, 2010
PubMed

Insights

Swine-origin influenza A H1N1 (S-OIV) in Indian children presented similarly to seasonal flu. Key findings include prolonged cough and lymphopenia (low lymphocyte count) in S-OIV positive cases.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Swine-origin influenza A H1N1 (S-OIV) has not been systematically studied in Indian children.
  • Understanding S-OIV's impact on pediatric populations in India is crucial for public health preparedness.

Purpose of the Study:

  • To investigate the clinical features, morbidity, and mortality patterns of S-OIV infection in children in India.
  • To characterize the epidemiological and clinical profile of S-OIV in a pediatric cohort.

Main Methods:

  • Prospective study conducted in New Delhi during the S-OIV pandemic containment phase (June-August 2009).
  • Clinical evaluation of suspected S-OIV cases according to WHO guidelines.
  • RT-PCR testing of nasal and throat swabs, with laboratory tests (hemoglobin, leucocyte, platelet counts) and chest radiography.

Main Results:

  • Thirty-seven children were included; 21 tested positive for S-OIV via RT-PCR.
  • S-OIV positive children exhibited a longer duration of cough (p<0.03).
  • Significantly lower total leucocyte (p<0.001) and lymphocyte counts (p<0.02) were observed in the S-OIV group. Oseltamivir-related gastritis occurred in 38% of treated children.

Conclusions:

  • S-OIV infection in Indian children shares clinical characteristics with seasonal influenza.
  • Lymphopenia is identified as a significant hematological feature of S-OIV infection in this pediatric cohort.
  • All children in the study recovered and were discharged, indicating favorable outcomes with treatment.
Abstract

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