[First live birth in Bulgaria after in vitro maturation (IVM) procedure (case report)]

The objective is to report the first healthy live birth in Bulgaria from immature oocytes retrieved in a natural menstrual cycle, followed by in vitro maturation (IVM). In vitro maturation protocol was performed in a case with male factor of infertility. Twentyone immature oocytes were retrieved by transvaginal ultrasound guided follicle aspiration on day 10 of a 28-year-old woman and matured in vitro. 28 hours late, 14 of them were in metaphase II. After insemination 13 were fertilizated. Three embryos were transfered at day two. The woman went on to deliver a single healthy live baby at term. We provide proof-of-principle evidence that the novel strategy of infertility treatment by IVM protocol can lead to successful pregnancy and healthy live birth.