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Updated: Jun 15, 2026
06:08
Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
[Stability of some medicinal solutions with captopril]
Silvia Imre1, Szende Vancea, Daniela Lucia Muntean
1Facultatea de Farmacie, Disciplina de Analiza Medicamentului, Universitatea de Medicină si Farmacie din Târgu-Mureş.
Summary
Oral liquid formulations with captopril (1 mg/ml) and ascorbic acid demonstrated stability for seven days at controlled temperatures. This offers a safer alternative for pediatric therapy compared to traditional tablet powders.
Area of Science:
- Pharmaceutical Sciences
- Formulation Development
- Drug Stability
Context:
- Captopril is an important medication, often administered orally.
- Pediatric patients may face challenges with traditional solid dosage forms.
- Liquid formulations offer potential advantages in drug delivery and administration.
Purpose:
- To evaluate the stability of simple oral liquid formulations containing 1 mg/ml captopril.
- To assess the impact of storage conditions (below 8°C and 22±3°C) on formulation integrity.
- To determine the suitability of these formulations as a safer alternative for pediatric captopril therapy.
Summary:
- Oral liquid formulations of captopril (1 mg/ml) were prepared with minimal excipients.
- Stability testing included physical, chemical, and microbiological analyses over 39 days.
- Formulations incorporating ascorbic acid exhibited stability for seven days at both 8°C and 22°C.
Impact:
- The study highlights the potential of simple liquid captopril formulations for pediatric use.
- Ascorbic acid inclusion enhances the stability of these oral solutions.
- Hospital pharmacies can potentially prepare these stable formulations as a safer alternative to captopril powders or tablets for children.
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