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Related Concept Videos

Van der Waals Interactions01:24

Van der Waals Interactions

Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.Polar molecules have a partial positive charge on one end and a partial negative charge on the other end of the molecule,...

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Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

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Published on: December 25, 2017

Flow induced dispersion analysis quantifies noncovalent interactions in nanoliter samples.

Henrik Jensen1, Jesper Østergaard

  • 1Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. hj@farma.ku.dk

Journal of the American Chemical Society
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

Flow Induced Dispersion Analysis (FIDA) is a novel method for studying noncovalent interactions using minimal samples. This technique provides diffusivities for both free analytes and complexes, simplifying interaction characterization.

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Area of Science:

  • Analytical Chemistry
  • Biophysical Chemistry
  • Physical Chemistry

Background:

  • Characterizing noncovalent interactions is crucial in various scientific fields.
  • Existing methods can be complex, time-consuming, or require larger sample volumes.

Purpose of the Study:

  • To introduce Flow Induced Dispersion Analysis (FIDA) as a new, efficient technique for analyzing noncovalent interactions.
  • To demonstrate FIDA's capability in determining analyte and complex diffusivities.

Main Methods:

  • Utilizing pressure-driven flows within micrometer-sized fused silica capillaries.
  • Analyzing temporal signal variances generated by the flow.
  • Implementing Flow Induced Dispersion Analysis (FIDA) for data acquisition.

Main Results:

  • FIDA requires only nanoliter sample volumes, making it highly sample-efficient.
  • The method is straightforward to implement and operate.
  • FIDA successfully provides quantitative diffusivities for both free analytes and their formed complexes.

Conclusions:

  • Flow Induced Dispersion Analysis (FIDA) offers a powerful and accessible new approach for characterizing noncovalent interactions.
  • The technique's low sample requirement and ease of use make it broadly applicable.
  • FIDA enhances the ability to study molecular interactions through precise diffusivity measurements.