Related Experiment Video
Updated: Jun 15, 2026
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Diabetic kidney disease: act now or pay later
Robert C Atkins1, Paul Z Zimmet,
1Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, Australia.
The Medical Journal of Australia
|March 6, 2010
Summary
The global rise in diabetes is causing a significant increase in diabetic kidney disease, particularly in developing nations. Urgent, multi-level action is needed to prevent diabetes and manage kidney complications.
Area of Science:
- Nephrology
- Endocrinology
- Public Health
Background:
- The 21st century presents a diabetogenic environment, leading to a projected 380 million people with diabetes globally by 2025.
- Diabetes is the primary cause of end-stage kidney disease worldwide, with 20%-40% of dialysis patients being diabetic.
- Australia has seen a fivefold increase in type 2 diabetes patients starting dialysis between 1993 and 2007.
Purpose of the Study:
- To highlight the escalating global burden of diabetic kidney disease.
- To advocate for immediate, multi-level interventions to combat type 2 diabetes and its renal complications.
- To emphasize the need for increased awareness, early screening, and effective treatments for diabetic kidney disease.
Main Methods:
- This study is a review and call to action based on current epidemiological data and clinical observations.
- It synthesizes global trends in diabetes and kidney disease prevalence.
- It outlines essential strategies for prevention, screening, treatment, and research.
Main Results:
- Diabetes is a major and growing cause of end-stage kidney disease globally.
- Developing countries are experiencing the fastest rise in diabetes prevalence.
- A significant proportion of dialysis patients have diabetes, with notable increases in specific regions like Australia.
Conclusions:
- Urgent, coordinated action at local, national, and international levels is critical to prevent type 2 diabetes.
- Early screening for diabetic kidney disease, public awareness, and evidence-based treatments are essential.
- Continued research and clinical trials for new therapies are necessary to manage and control diabetic kidney disease.
Related Concept Videos
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...