Related Experiment Video

Updated: Jun 15, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Oral glucose tolerance testing in children with cystic fibrosis

Katie Larson Ode1, Brigitte Frohnert, Theresa Laguna

  • 1Department of Pediatrics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.

Pediatric Diabetes
|March 6, 2010
PubMed

Insights

Abnormal glucose tolerance in young children with cystic fibrosis (CF) indicates a high risk for developing early-onset diabetes. This finding supports earlier screening for CF-related diabetes in this vulnerable population.

Area of Science:

  • Pediatric Endocrinology
  • Cystic Fibrosis Research
  • Metabolic Disorders

Background:

  • Cystic fibrosis (CF)-related diabetes is the most frequent comorbidity in CF patients.
  • Current guidelines suggest annual oral glucose tolerance testing (OGTT) for CF patients starting at age 10.
  • The prognostic value of OGTT in younger children with CF is not well-established.

Purpose of the Study:

  • To determine if OGTT findings in children with CF aged 6-9 predict their subsequent clinical course.
  • To assess the utility of early OGTT screening for identifying children at risk of developing CF-related diabetes.

Main Methods:

  • A retrospective matched-pair cohort study analyzed OGTT data from 1998-2003.
  • Children aged 6-9 were categorized into normal glucose tolerance (NGT) and abnormal glucose tolerance (AGT) groups.
  • Clinical status and diabetes development were assessed at baseline and 5 years later.

Main Results:

  • Children with AGT showed a significantly higher incidence of diabetes (42%) compared to those with NGT (3%) within 5 years.
  • The odds of developing diabetes were 11 times higher in the AGT group (p=0.0009).
  • Diabetes onset occurred at a much earlier age (11-12 years) in the AGT group compared to the general CF population (approx. 23 years).

Conclusions:

  • Abnormal glucose tolerance in children with CF aged 6-9 is a strong predictor of early-onset diabetes.
  • These findings support the potential benefit of OGTT screening in younger children with CF.
  • Early identification of AGT can help in timely intervention for CF-related diabetes.
Abstract

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)

Published on: January 7, 2018

Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...