Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Assembly of type C oncornaviruses: a model.

D P Bolognesi, R C Montelaro, H Frank

    Science (New York, N.Y.)
    |January 13, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Sensitive and rapid analysis of nitrophenols and herbicides by capillary zone electrophoresis (CZE)].

    Se pu = Chinese journal of chromatography·2003
    Same author

    Cardiovascular effects of beta-blockers with and without intrinsic sympathomimetic activity. A comparison between celiprolol and metoprolol.

    Kidney & blood pressure research·2002
    Same author

    Afterload reduction in severe aortic regurgitation.

    Journal of magnetic resonance imaging : JMRI·2001
    Same author

    Long-term results after microvascular decompression in essential hypertension.

    Stroke·2001
    Same author

    Capillary electrophoresis with on-chip four-electrode capacitively coupled conductivity detection for application in bioanalysis.

    Electrophoresis·2001
    Same author

    Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

    This study reveals how oncornavirus assembly occurs via precursor molecules recognizing viral RNA and envelope proteins. Maturation involves specific cleavage and organization into type C virion structures.

    Area of Science:

    • Virology
    • Molecular Biology
    • Cell Biology

    Background:

    • Oncornaviruses are retroviruses known for causing tumors.
    • Understanding virus assembly is crucial for developing antiviral strategies.

    Purpose of the Study:

    • To elucidate the molecular mechanisms of oncornavirus assembly.
    • To describe the process of type C virion formation.

    Main Methods:

    • Analysis of precursor polypeptide interactions.
    • Observation of viral component alignment at the cell membrane.
    • Electron microscopy of virion substructures.

    Main Results:

    • Uncleaved precursor polypeptides contain recognition sites for viral envelope proteins and RNA.

    Related Experiment Videos

  • Specific alignment of viral components occurs at the budding site.
  • Proteolytic cleavage of precursors and subsequent association form type C virions.

    • Conclusions:

    • Oncornavirus assembly is a highly ordered process involving specific molecular recognition and proteolytic maturation.
    • The described model provides a framework for understanding type C retroviral particle formation.