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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Biomarkers in lupus nephritis.
Anup Manoharan1, Michael P Madaio
1Department of Medicine, Nephrology and Kidney Transplantation Section, Medical College of Georgia, 1120 15th Street, BA 9413, Augusta, GA 30912-3140, USA. AMANOHARAN@mail.mcg.edu
Rheumatic Diseases Clinics of North America
|March 6, 2010
Summary
Novel biomarkers show promise for noninvasively managing lupus nephritis. Combinations of biomarkers, rather than single markers, may predict disease severity and treatment response, potentially reducing the need for renal biopsies.
Area of Science:
- Nephrology
- Immunology
- Translational Medicine
Background:
- Lupus nephritis diagnosis and management often rely on invasive renal biopsies.
- Candidate biomarkers for lupus nephritis have been identified but require further validation.
- Current management strategies aim to improve therapeutic efficacy and reduce treatment toxicity.
Purpose of the Study:
- To explore the potential of noninvasive biomarkers for evaluating and managing lupus nephritis.
- To identify promising biomarker combinations for predicting disease severity, fibrosis, and drug responsiveness.
- To reduce reliance on renal biopsies and improve patient outcomes.
Main Methods:
- Review and synthesis of existing research on lupus nephritis biomarkers.
- Identification of candidate serum and urinary biomarkers for validation.
- Exploration of integrated approaches combining biomarkers, genotype, and clinical presentation.
Main Results:
- Candidate biomarkers like serum erythrocyte bound complement C4d, IL-17, IL-23, interferon/chemokine score ratio, and anti-C1q antibodies show potential.
- Urinary biomarkers such as fractional excretion of endothelial-1, MCP-1, VCAM-1, and TWEAK require further validation.
- Biomarker profiles and algorithms integrating genotype and clinical data are anticipated for improved management.
Conclusions:
- Biomarker combinations offer a promising noninvasive strategy for lupus nephritis management.
- Validated biomarker panels could guide treatment decisions, reduce renal biopsies, and improve patient outcomes.
- Future research should focus on large-scale validation of identified biomarkers and integrated diagnostic algorithms.
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