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Cell-bound complement biomarkers for systemic lupus erythematosus: from benchtop to bedside

Chau-Ching Liu1, Susan Manzi, Amy H Kao

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Rheumatic Diseases Clinics of North America
|March 6, 2010
PubMed

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...