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Updated: Jun 15, 2026

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
Regulatory roles of the bacterial nitrogen-related phosphotransferase system
Katharina Pflüger-Grau1, Boris Görke
1Systems Biology Program, Centro Nacional de Biotecnología (CNB-CSIC), 28049 Cantoblanco-Madrid, Spain.
Abstract:
In addition to the sugar phosphotransferase system (sugar PTS) dedicated to carbohydrate uptake, many Gram-negative bacteria possess a so-called nitrogen PTS (PTS(Ntr)). Although fulfilling very different functions, both systems can communicate with each other by phosphate exchange. PTS(Ntr) regulates diverse processes implicated in metabolism of nitrogen and carbon, and is essential for virulence in some bacteria. Additionally, it plays a role in potassium homeostasis by regulating the expression and activity of a high- and a low-affinity K(+) transporter, respectively. In this article, we review recent advances in the understanding of the regulatory roles of PTS(Ntr) in various organisms.
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