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Related Experiment Video

Updated: Jun 15, 2026

Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure

Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure

Published on: May 27, 2022

Yeasts: neglected pathogens.

Daniel Poulain¹, Boualem Sendid, Annie Standaert-Vitse

¹Université Lille Nord de France, UDSL, CHU Lille, Inserm U799, Inserm U795, Lille, France. dpoulain@univ-lille2.fr

Digestive Diseases (Basel, Switzerland)

|March 6, 2010

Summary

This summary is machine-generated.

Candida albicans colonization is linked to Crohn's disease (CD) development. This yeast triggers antibodies (ASCA) and inflammation, suggesting its role in CD pathogenesis in susceptible individuals.

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Area of Science:

Immunology
Microbiology
Gastroenterology

Background:

Crohn's disease (CD) involves immune system loss of tolerance to microbes.
CD patients exhibit antibodies against yeast oligomannosides (ASCA).
Candida albicans, a common commensal, is investigated for its role in CD.

Purpose of the Study:

To investigate the role of Candida albicans in Crohn's disease pathogenesis.
To explore the link between C. albicans colonization, immune response, and CD development.

Main Methods:

Serological analysis for antibodies against C. albicans components (oligomannose, chitin, glucan).
Mycological investigation of C. albicans colonization in CD patients and families.
Experimental induction of colitis and C. albicans colonization in mice.

Main Results:

C. albicans expresses epitopes recognized by ASCA and other CD-associated antibodies (ALCA, ACCA).
CD patients and relatives show higher C. albicans colonization rates.
In mice, C. albicans colonization exacerbates colitis, increasing inflammation and cytokine expression.

Conclusions:

C. albicans is implicated as an immunogen in CD, triggering specific antibody responses.
Interactions between immune receptors (TLRs, lectins) and C. albicans glycans influence the immune response in CD.