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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jun 15, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Link between interleukin-10 level and outcome after ischemic stroke.

Li-Teh Chang¹, Chun-Man Yuen, Chia-Wei Liou

¹Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology, Ping Tung, Taiwan, ROC.

Neuroimmunomodulation

|March 6, 2010

Summary

Serum interleukin-10 (IL-10) levels are elevated after acute ischemic stroke (IS) and predict patient outcomes. Higher IL-10 levels correlate with severe neurological impairment and adverse clinical events.

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Last Updated: Jun 15, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Area of Science:

Neuroscience
Immunology
Clinical Medicine

Background:

The prognostic significance of interleukin-10 (IL-10) following acute ischemic stroke (IS) remains unclear.
IL-10 is a key cytokine involved in immune regulation, with potential roles in stroke pathophysiology.

Purpose of the Study:

To investigate the prognostic value of serum IL-10 levels in patients post-acute IS.
To determine if elevated IL-10 levels after IS predict clinical outcomes.

Main Methods:

Serum IL-10 levels were measured 48 hours after acute IS in 135 patients.
Control groups included 20 healthy individuals and 30 at-risk individuals.
Neurological impairment was assessed using the National Institute of Health Stroke Scale (NIHSS).

Main Results:

IS patients exhibited significantly higher mean serum IL-10 compared to both control groups (p < 0.0001).
Elevated IL-10 levels were observed in patients with severe neurological impairment (NIHSS ≥12) versus those with less severe impairment (p < 0.0001).
Higher serum IL-10 strongly and independently correlated with severe neurological impairment and predicted major adverse clinical outcomes at 90 days (p < 0.0001).

Conclusions:

Serum IL-10 serves as an independent prognostic marker for outcomes in patients following acute ischemic stroke.
Elevated IL-10 levels are associated with stroke severity and long-term adverse events.