Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of N-methyl-D-aspartate responses by noradrenaline in the rat motorcortex in vivo.

C Lehmenkühler1, J Walden, E J Speckmann

  • 1Institut für Physiologie, Universität Münster, F.R.G.

Neuroscience Letters
|January 2, 1991
PubMed
Summary

Noradrenaline (NA) reduces N-methyl-D-aspartate (NMDA) induced changes in rat motor cortex potentials. This effect, mediated by alpha-1 adrenoceptors, suggests an intracellular pathway influencing NMDA receptor activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Katayama et Al.: therapeutic window of lamotrigine for mood disorders: a naturalistic retrospective study. Pharmacopsychiatry 2014; 47: 111-114.

Pharmacopsychiatry·2014
Same author

Anticonvulsant drugs in bipolar disorder.

Dialogues in clinical neuroscience·2011
Same author

Topography and bioelectrical properties of identifiable neurons in the buccal ganglion of Helix pomatia.

Neuroscience letters·2009
Same author

Effects of pentylenetetrazol on resting membrane potential and on action potentials of mammalian dorsal root ganglion cells grown in tissue culture.

Neuroscience letters·2009
Same author

Dependency of the resting membrane potential on the extracellular chloride concentration in identified neurons of Helix pomatia.

Neuroscience letters·2009
Same author

Hyperbaric oxygen in neurosurgery.

Acta neurochirurgica·2009

Area of Science:

  • Neuroscience
  • Neuropharmacology

Background:

  • Noradrenaline (NA) is a key neurotransmitter in the central nervous system.
  • N-methyl-D-aspartate (NMDA) receptors are crucial for synaptic plasticity and excitability.

Purpose of the Study:

  • To investigate the influence of noradrenaline on NMDA-induced cortical field potentials (CFPs) in the rat motor cortex.
  • To elucidate the specific adrenoceptor subtypes involved in this interaction.

Main Methods:

  • Anesthetized and ventilated rats were used to record motor cortex CFPs.
  • NMDA and NA were applied via micropipette pressure ejection into different cortical laminae.
  • Selective alpha-1 (phenylephrine), alpha-2 (clonidine), and beta (isoproterenol) adrenoceptor agonists were used to probe receptor involvement.

Related Experiment Videos

Main Results:

  • NMDA application induced negative CFPs, while NA produced minimal effects alone.
  • NA significantly decreased the amplitude of NMDA-induced negative CFPs.
  • Alpha-1 agonist phenylephrine mimicked NA's inhibitory effect, while clonidine showed mixed results, and isoproterenol had no effect.

Conclusions:

  • Noradrenaline diminishes NMDA-induced cortical activity in the motor cortex.
  • The alpha-1 adrenoceptor appears to mediate this inhibitory effect.
  • An intracellular signaling pathway is likely involved in modulating NMDA receptor function by NA.