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Related Experiment Video

Updated: Jun 15, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
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Near infrared spectroscopy: guided tilt table testing for syncope.

Rohit P Rao1, Michael J Danduran, Jennifer E Dixon

  • 1Department of Pediatrics, Division of Cardiology and Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA. rrao@chw.org

Pediatric Cardiology
|March 6, 2010
PubMed
Summary

Near-infrared spectroscopy (NIRS) monitoring during head-up tilt-table tests (HUTT) reveals distinct regional oxygenation patterns in patients experiencing syncope. These findings help understand the physiological basis of syncope during postural challenges.

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Area of Science:

  • Cardiology
  • Neurology
  • Physiology

Background:

  • Syncope, a transient loss of consciousness, is commonly caused by neurocardiogenic syncope (NCS).
  • The head-up tilt-table test (HUTT) is a standard diagnostic tool for NCS.
  • Near-infrared spectroscopy (NIRS) offers noninvasive, continuous monitoring of regional tissue oxygenation (rSO2).

Purpose of the Study:

  • To investigate differential desaturation patterns in cerebral and renal vascular beds using multisite NIRS during HUTT.
  • To correlate NIRS findings with physiological events during orthostatic stress in patients with syncope.

Main Methods:

  • Recruited patients aged 7-21 years undergoing HUTT.
  • Utilized two NIRS probes placed on the forehead (cerebral) and paravertebral region (renal).

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Last Updated: Jun 15, 2026

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  • Recorded regional tissue oxygenation (rSO2) at rest, during HUTT, and recovery.

    • Main Results:

    • Patients with syncope exhibited distinct rSO2 trends compared to normal subjects.
    • Cerebral rSO2 decreased, indicating hypoperfusion, preceding syncope symptoms.
    • A concurrent increase in cerebral rSO2 was paralleled by renal rSO2, returning to baseline upon supine positioning.

    Conclusions:

    • Multisite NIRS during HUTT demonstrates differential vascular bed responses to postural stress.
    • Observed rSO2 patterns reflect systemic oxygen consumption and flow-coupling dynamics during syncope.