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Pregnancy and Nursing Management for Embryo-Transferred and Genetically Modified Rabbits
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Genetically modified animals and pharmacological research.

Dominic J Wells1

  • 1Department of Veterinary Basic Sciences, Royal Veterinary College, London NW1OTU, UK. dwells@rvc.ac.uk

Handbook of Experimental Pharmacology
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

Genetically modified animals offer insights into gene function and disease modeling. Applications range from enhanced food production and xenografting to producing biopharmaceuticals and developing novel genetic therapies for domestic animals.

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Area of Science:

  • Animal genetics
  • Biotechnology
  • Genomics

Background:

  • Advances in understanding domestic animal genomes.
  • Growing applications of genetic modification techniques.

Purpose of the Study:

  • To review the use of genetically modified animals.
  • To outline different genetic modification approaches, their advantages, and disadvantages.
  • To explore current and future applications in various domestic species.

Main Methods:

  • Review of genetic modification techniques.
  • Analysis of applications in mice, farm animals, and other domestic species.
  • Discussion of genome knowledge in domestic species.

Main Results:

  • Genetically modified mice are crucial for gene function studies and disease models.
  • Transgenic farm animals are developed for improved nutrition, disease resistance, and xenografting.
  • Domestic animals serve as bioreactors for biopharmaceutical production ('pharming') and as targets for genetic therapies.

Conclusions:

  • Genetically modified animals have diverse applications, from research to therapeutic development.
  • The use of genetically modified animals is expanding, with significant potential in future therapies.
  • Domestic animals are increasingly important for both understanding and treating diseases through genetic interventions.