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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 15, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

miRBase: microRNA sequences and annotation.

Sam Griffiths-Jones¹

¹University of Manchester, Manchester, United Kingdom.

Current Protocols in Bioinformatics

|March 6, 2010

Summary

This summary is machine-generated.

miRBase is the central repository for microRNA (miRNA) sequence information, providing a vital resource for researchers. It offers comprehensive data, nomenclature, and search functionalities for published miRNA sequences.

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Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

MicroRNAs (miRNAs) are crucial regulatory molecules.
A centralized, standardized repository for miRNA data is essential for research.
miRBase serves as this central hub for miRNA sequence information.

Purpose of the Study:

To describe the miRBase database as the primary resource for miRNA sequence information.
To highlight miRBase's role in miRNA nomenclature and data accessibility.
To outline the functionalities and data retrieval methods offered by miRBase.

Main Methods:

Curating and maintaining a comprehensive database of published miRNA sequences.
Developing standardized nomenclature for miRNA genes.
Implementing search functionalities for sequence and text-based queries.
Providing data access via an online portal and FTP site.

Main Results:

miRBase is established as the definitive repository for miRNA sequences.
It facilitates standardized naming of novel miRNAs.
The database offers integrated access to sequences, annotations, and literature links.
Comprehensive data download options are available.

Conclusions:

miRBase is an indispensable resource for the miRNA research community.
Its role in standardization and data accessibility significantly advances the field.
The database supports diverse research needs through its search and download capabilities.