Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Extent Of Gender/Sex Variables Included In Clinical Algorithms Across Medical Specialties.

Health affairs (Project Hope)·2026
Same author

Declarations of Independence - Physicians and the U.S. Body Politic, 1776-2026.

The New England journal of medicine·2026
Same author

Prescription without Precision - Dangers of Dosing on the Basis of Race as Biology.

The New England journal of medicine·2026
Same author

Carbon Dots and Their Functionalization with Photosensitizer Chlorin E6: Advancing Antibacterial Efficacy Through Enhanced Photodynamic Effects.

Pharmaceutics·2026
Same author

A Eulogy for Structural Competence?

The New England journal of medicine·2026
Same author

The Rise, Fall, and Laser Resurrection of the "Snake Heart" Operation.

Journal of the history of medicine and allied sciences·2026

Related Experiment Video

Updated: Jun 15, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Triggered drug delivery from biomaterials.

Colin P McCoy1, Christopher Brady, John F Cowley

  • 1Queen's University Belfast, School of Pharmacy, 97 Lisburn Road, Belfast, UK. c.mccoy@qub.ac.uk

Expert Opinion on Drug Delivery
|March 9, 2010
PubMed
Summary

Controlled drug delivery from implants is crucial for patient needs. This review explores triggered release systems, offering tailored drug delivery for improved medical devices and therapies.

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Related Experiment Videos

Last Updated: Jun 15, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Medical Device Engineering

Background:

  • Conventional drug dosing often fails to meet patient requirements.
  • Controlling drug release from implanted materials is challenging but promising for medical applications.
  • Applications include infection-resistant devices and responsive implants for diabetes management.

Purpose of the Study:

  • To review recent advancements in triggered drug release from implantable biomaterials.
  • To provide an overview of stimuli-responsive systems for modulated drug delivery.

Main Methods:

  • Classification of triggers based on responsiveness to chemical species, light, heat, magnetism, ultrasound, and mechanical force.
  • Review of recent and historical reports on triggered drug delivery systems.

Main Results:

  • Triggered drug delivery enables precise control over the dose, location, and timing of drug release.
  • Offers solutions for drugs where traditional dosing methods are inadequate.
  • Highlights the potential for tailoring drug release profiles for various therapeutic needs.

Conclusions:

  • Externally or internally applied triggers significantly enhance drug delivery modalities.
  • Triggered release systems hold potential for improved infection resistance in biomaterials.
  • This approach promises advanced therapeutic strategies and improved patient outcomes.